NEWS & Featured Publications

The Jeon Lab Microfluidic Neuron Device is now commercially available through

On The Cover! (Left) Journal of Neuroscience Methods. 2008 May 30;170(2):188-96

Microfluidic-based strip assay for testing the effects of various surface-bound inhibitors in spinal cord injury.
Vahidi B, Park JW, Kim HJ, Jeon NL.

Cover (left) Description: Microfluidics and surface micropatterning methods are combined to develop a drug screening platform for spinal cord injury and for axonal regeneration research. Cells (stained green) are selectively placed on a band coated with Polylysine. The immediate areas to the left and right are patterned with alternating strips of polylysine and Chondroitin Sulfate Proteoglycan. The axons (stained green) grow only on the strips coated with polylysine.

Biological Applications of Microfluidics Chapter 6 pages 115 - 132 Microfluidic Culture Platforms For Stem Cell And Neuroscience Research
Chung BC, Vahidi B, Park JW, Hu JS, Harris JW, Monuki ES, Jeon NL

Generation of Stable Complex Gradients Across Two-Dimensional Surfaces and Three-Dimensional Gels. (Left)

Langmuir. 2007 Oct 23;23(22):10910-10912. Epub 2007 Oct 2 Mosadegh B, Huang C, Park JW, Shin HS, Chung BG, Hwang SK, Lee KH, Kim HJ, Brody J, Jeon NL.

JOVE Video: Fabrication of a Microfluidic Device for the Compartmentalization of Neuron Soma and Axons

JOVE Video: Preparing E18 Cortical Rat Neurons for Compartmentalization in a Microfluidic Device

JOVE Video: Non-plasma bonding of PDMS for inexpensive fabrication of microfluidic device

Lab On A Chip

Miniaturisation for Chemistry, Biology & Bioengineering

Vascular mimetics based on microfluidics for imaging the leukocyte--endothelial inflammatory response.

Lap On A Chip - The ten most accessed articles in April 2007

Also On the Cover April 2007 7(4): 448 (left)

Lab Chip. 2007 Apr;7(4):448-56. Epub 2007 Jan 23.
Schaff UY, Xing MM, Lin KK, Pan N, Jeon NL, Simon SI.

Nature Methods Vol. 2 No. 8 August 2005 A microfluidic culture platform for CNS axonal injury, regeneration, and transport

Microfabrication techniques have been around for many years and used extensively in the semiconductor industry for making various micron-scale (and sub micron-scale) devices, such as integrated circuits and computer chips. The last few years, however, saw the applications for these technologies take a new turn, as they began to be implemented in biology, biochemistry, and biomedical devices. Processes that were used to produce oscillators and resonators were now being used to analyze DNA samples, run enzymatic reactions, and study cellular processes. The term MEMS (microelectromechanical systems), which was used to describe traditional microdevices, became too limited, and the fields of BioMEMS (biomedical microelectromechanical systems) and microfluidics emerged.
Our lab focuses on applying microfluidics to biology, by using soft-lithography and rapid prototyping to study processes such as cell attachment, cell movement, and cell-cell interactions in controlled environments.
The interdisciplinary nature of this field is reflected by the diverse backgrounds of the group members and the nature of their projects. People specializing in chemistry, biology, material science, and physics tackle projects in chemotaxis, neuroscience, and tissue engineering. These various areas of expertise complement each other very well, and provide a strong foundation for exciting research in biomedical engineering.

Last Updated on September 21st, 2008.

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